Lee (1-0) didn't win his first game last year until July 4, but the former Cy Young Award winner outpitched Kris Medlen (0-1) with temperatures in the low 40s and a light mist falling most of the game.
Philadelphia scored two runs in the second on Ben Revere's fielder's choice RBI and Chase Utley's sacrifice fly RBI.
After Lee watched Cole Hamels and Roy Halladay lose the first two games by a combined 16-7 score, the left-hander walked none and struck out eight in 106 pitches to give the Phillies' renowned threesome a big lift.
Lee left for pinch-hitter Freddy Galvis in the ninth. Jonathan Papelbon earned his first save.
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