Tim Duncan added 16 points, Danny Green had 13 and Gary Neal had 12 for San Antonio, which has won 10 straight at home.
Tiago Splitter had 12 points and 10 rebounds.
Spencer Hawes had a game-high 22 points for Philadelphia, which has lost three straight and five of six.
Evan Turner added 12 points and Thaddeus Young, Jason Richardson and Jrue Holiday each added 11.
San Antonio rebounded from a blowout loss Thursday against the New York Knicks to improve to 14-2 at home.
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