Jackson, who had three hits, Pearce and Exposito homered in a four-run sixth inning off Toronto reliever Esmil Rogers. The home runs by Jackson and Pearce were back-to-back.
The Orioles also homered four times on Sunday against Philadelphia.
J.A. Happ started for Toronto and allowed Pearce's first homer - a two-run shot - in three innings.
Baltimore's Steve Johnson gave up two runs in two innings, and Jair Jurrjens allowed three runs and five hits in 2 2-3 innings.
The teams combined for 29 hits.
Alexi Casilla had three hits for the Orioles.
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