Myers opened the game with a drive to center and Rodriguez hit a two-run shot in the third. Both home runs came against Chen, who lasted only 3 2-3 innings.
Nix connected off South Korean right-hander Suk-Min Yoon, who gave up two hits over two innings in his second appearance. He was sent to the team's minor league camp after the game.
Chen gave up three runs and nine hits over nine innings in his first three starts before struggling against the Rays, who finished with 14 hits after getting 20 on Tuesday night against Minnesota.
Adam Jones homered and scored three runs for the Orioles. Chris Davis hit an RBI single and is batting .480 this spring.
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